Single-Cell Pathology™ISOLATING AND VISUALIZING RARE CELLS
Single Cell Pathology
X-ZELL’s patented and proprietary platform technology – we call it Single Cell Pathology – is able to isolate and visualize a variety of rare cells in a small 10ml blood sample – including tumour-derived Circulating Endothelial Cells (CEC), Circulating Tumor Cells (CTC) and circulating tumour microemboli [3,4,5].
It is based on four core modules, all of which have been developed in-house and are now being made available to clinical study sites in Thailand and abroad, as well as select hospitals in Thailand.
Proprietary Cell Lysis
Cell lysis is the first step to clearing the blood from healthy cells and exposing rare, unwanted cells. To obtain the best possible yield and purity, X-ZELL has developed a unique process to free the sample from red blood cells whilst retaining eight out of ten cancer cells.
hMX™ Magnetic Cell Separation
High-gradient magnetic separation has established itself as the gold standard of cell separation, offering the highest magnetic field gradients available. However, if left untreated, its internal ferromagnetic matrix leads to high non-specific cell retention during separation. Our patented, buffer-optimized, high-gradient magnetic cell separation (hMX™) system avoids non-specifc binding by competitively blocking non-specific binding sites. With flow channels several hundred micrometres wide, it provides optimal recovery of large cells and even cell clumps.
Stop optimizing, start discovering: Cryoimmunostaining™ is designed to perform all stages of multi-plexed immunostaining – from cell fixation to counterstaining – allowing you to examine up to ten markers on a single cell without any digital image processing. Using standard laboratory slides and commercially available fluorophore-conjugated antibodies, Cryoimmunostaining™ is a complete platform solution with a focus on quality and reproducibility. Send us an email (use form below) to learn more about custom applications today. ell clumps.
Automated Microscopic Analysis
X-ZELL has refined semi-automated widefield fluorescence microscopy to identify and analyze cancer cells on a standard laboratory slide – allowing for classic cancer pathology to be applied to circulating tumour-derived cells at the single cell level. Well-described hallmarks of cancer can be re-discovered in isolated cancer cells and cell clumps, including aneuploidy, polyploidy, the expression of stem cell markers, mesenchymal makers, epithelial markers, cell proliferation markers, apoptotic markers and more, enabling diagnostics based on solid visual evidence.e button below.
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